Sustained Diet-Induced Remission in Pediatric Crohn's Disease Is Associated With Kynurenine and Serotonin Pathways.
Ghiboub, Mohammed PhD; Boneh, Rotem Sigall RD; Sovran, Bruno PhD; Wine, Eytan MD, PhD; Lefevre, Antoine; Emond, Patrick PharmD, PhD; Verburgt, Charlotte M MD; Benninga, Marc A MD, PhD; de Jonge, Wouter J PhD; Van Limbergen, Johan E MD, PhD
[Miscellaneous Article]
Inflammatory Bowel Diseases.
29(5):684-694, May 02, 2023.
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Lay Summary: We show that fecal tryptophan metabolites are associated with remission following dietary therapy in a prospective clinical trial of pediatric Crohn's disease patients. Our study shows that reduction in some kynurenine pathway metabolites and the increase in serotonin pathway compounds are associated with diet-induced and sustained remission. These compounds may play a role in mediating the mechanism of action of dietary therapy.
(C) Crohn's & Colitis Foundation
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