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: For therapeutic plasma exchange (TPE), continuous and intermittent flow separators are known to be efficient. This study was undertaken to compare the performances of the Spectra Optia, a continuous flow centrifugal apheresis system recently developed by CaridianBCT, with the Haemonetics Multicomponents System (MCS) apheresis system based on intermittent flow centrifugation. The primary objective of the study was to compare the time required to exchange one total plasma volume with both separators. The secondary objectives were to determine the plasma exchange efficiency, the plasma extraction rate, the percentage of target exchange volume achieved, and the loss of cellular components. The study involved prospectively paired comparison of 16 TPE on each device performed in patients with chronic diseases treated with TPE. The time required to exchange 1 total plasma volume was 182 /- 36 minutes for MCS procedures and 100 /- 20 minutes for the Spectra Optia procedures (P < 0.05, all results presented as mean /- standard deviation). A significantly higher plasma extraction rate was achieved (30.2 /- 4.3 vs 16.8 /- 3.4 mL/min, respectively, P < 0.05), and the plasma exchange efficiency was slightly better with the Spectra Optia compared with the MCS procedures (83.4 /- 7.0 vs 80.0 /- 8.5%, P < 0.05). The platelet loss was significantly lower with the Spectra Optia compared with the MCS procedures (1.6 /- 2.3 vs 7.5 /- 4.2%, respectively, P < 0.05), whereas the red blood cells loss was comparable. In conclusion, the Spectra Optia has significantly higher extraction rate and exchange efficiency than the MCS allowing to remove the same amount of plasma in less time, by processing less blood. It also removes significantly less platelets than the MCS separator. J. Clin. Apheresis, 2011. (C) 2010 Wiley-Liss, Inc.

Copyright (C) 2011 John Wiley & Sons, Inc.