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Differences and Similarities Among COVID-19 Patients Treated in Seven ICUs in Three Countries Within One Region: An Observational Cohort Study*.
Mesotten, Dieter Prof 1,2; Meijs, Daniek A. M. BSc 3,4; van Bussel, Bas C. T. MD, PhD 3,5; Stessel, Bjorn MD, PhD 2,6; Mehagnoul-Schipper, Jannet MD, PhD 7; Hana, Anisa MD 4; Scheeren, Clarissa I. E. MD 8; Strauch, Ulrich MD 3; van de Poll, Marcel C. G. MD, PhD 3,9,10; Ghossein-Doha, Chahinda MD, PhD 3,11; Buhre, Wolfgang F. F. A. Prof 12; Bickenbach, Johannes Prof 13; Vander Laenen, Margot MD 1; Marx, Gernot Prof 13; van der Horst, Iwan C. C. Prof 3,11; COVID Data Platform (CoDaP) Investigators
[Article] Critical Care Medicine. 50(4):595-606, April 2022.

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OBJECTIVES: To investigate healthcare system-driven variation in general characteristics, interventions, and outcomes in coronavirus disease 2019 (COVID-19) patients admitted to the ICU within one Western European region across three countries.

DESIGN: Multicenter observational cohort study.

SETTING: Seven ICUs in the Euregio Meuse-Rhine, one region across Belgium, The Netherlands, and Germany.

PATIENTS: Consecutive COVID-19 patients supported in the ICU during the first pandemic wave.

INTERVENTIONS: None.

MEASUREMENTS AND MAIN RESULTS: Baseline demographic and clinical characteristics, laboratory values, and outcome data were retrieved after ethical approval and data-sharing agreements. Descriptive statistics were performed to investigate country-related practice variation. From March 2, 2020, to August 12, 2020, 551 patients were admitted. Mean age was 65.4 /- 11.2 years, and 29% were female. At admission, Acute Physiology and Chronic Health Evaluation II scores were 15.0 /- 5.5, 16.8 /- 5.5, and 15.8 /- 5.3 (p = 0.002), and Sequential Organ Failure Assessment scores were 4.4 /- 2.7, 7.4 /- 2.2, and 7.7 /- 3.2 (p < 0.001) in the Belgian, Dutch, and German parts of Euregio, respectively. The ICU mortality rate was 22%, 42%, and 44%, respectively (p < 0.001). Large differences were observed in the frequency of organ support, antimicrobial/inflammatory therapy application, and ICU capacity. Mixed-multivariable logistic regression analyses showed that differences in ICU mortality were independent of age, sex, disease severity, comorbidities, support strategies, therapies, and complications.

CONCLUSIONS: COVID-19 patients admitted to ICUs within one region, the Euregio Meuse-Rhine, differed significantly in general characteristics, applied interventions, and outcomes despite presumed genetic and socioeconomic background, admission diagnosis, access to international literature, and data collection are similar. Variances in healthcare systems' organization, particularly ICU capacity and admission criteria, combined with a rapidly spreading pandemic might be important drivers for the observed differences. Heterogeneity between patient groups but also healthcare systems should be presumed to interfere with outcomes in coronavirus disease 2019.