Peripheral Blood Mononuclear Cells from Infants Hospitalized Owing to Respiratory Syncytial Virus Infection Express T Helper-1 and T Helper-2 Cytokines and CC Chemokine Messenger RNA.
Tripp, Ralph A. 1; Moore, Deborah 1; Barskey, Albert IV 1; Jones, Les 1; Moscatiello, Caminade 2; Keyserling, Harry 2; Anderson, Larry J. 1
[Article] Journal of Infectious Diseases. 185(10):1388-1394, May 15, 2002.

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: The cellular immune response to respiratory syncytial virus (RSV) infection was examined in infants aged 1-21 months who were hospitalized because of RSV infection or non-RSV-related illness. RSV- or control-stimulated peripheral blood mononuclear cells were examined to determine RSV-specific intracellular T helper-1 (Th1) and T helper- 2 (Th2) cytokine expression, chemokine messenger RNA (mRNA) expression, and cell surface markers. Patients hospitalized because of RSV infection had increased numbers of CD16 and CD56bright cells and had RSV-specific increases in Th1 (interleukin [IL]-2 and interferon-[gamma]) and Th2 (IL-4 and IL-6) cytokines and CC chemokines (macrophage inflammatory protein [MIP]-1[alpha], MIP-1[beta], and RANTES [regulated on activation, normally T cell expressed and secreted]) mRNA expression. The results suggest that RSV infection induces both Th1 and Th2 cytokine expression and CC chemokine expression.

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