Information de reference pour ce titreAccession Number: | 00080647-201001200-00011.
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Author: | Montoro, Paola a,*; Maldini, Mariateresa a; Piacente, Sonia a; Macchia, Mario b; Pizza, Cosimo a
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Institution: | (a)Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Salerno, via Ponte don Melillo, 84084 Fisciano (SA), Italy (b)Dipartimento di Agronomia e Gestione dell'Agroecosistema, Universita di Pisa, Via S. Michele degli Scalzi 2, 56124 Pisa, Italy
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Title: | |
Source: | Journal of Pharmaceutical and Biomedical Analysis. 51(2):405-415, January 2010.
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Abstract: | The major phytochemical constituents, namely, alkaloids, flavonoids and ellagic acid derivatives, of leaves of Camptotheca acuminata were identified using high performance liquid chromatography (HPLC) coupled with electrospray mass spectrometry (ESI-MS) in extracts of plants cultivated in Italy and collected at different growth stages. Alkaloids related to camptothecin were identified and quantified by HPLC coupled with ESI-tandem mass spectrometry (MS/MS) employing, respectively, an ion trap and a triple quadrupole mass analyser. The fragmentation patterns of alkaloids related to camptothecin were analysed and a specific Multiple Reaction Monitoring HPLC-MS/MS method was developed for the quantitative determination of these constituents. The described method provides high sensitivity and specificity for the characterisation and quantitative determination of the alkaloids in C. acuminata.
(C) 2010Elsevier, Inc.
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Author Keywords: | HPLC-MS/MS; Camptothecin; Camptotheca acuminata; Alkaloid determination; Fragmentation mechanism.
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Language: | English.
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Document Type: | Article.
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Journal Subset: | Pharmacology.
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ISSN: | 0731-7085
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DOI Number: | https://dx.doi.org/10.1016/j.jpb...- ouverture dans une nouvelle fenêtre
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