Plasma Plasminogen Activator Inhibitor-1 Levels and Nonalcoholic Fatty Liver in Individuals With Features of Metabolic Syndrome.
de Larranaga, Gabriela PhD; Wingeyer, Silvia Peres PhD; Graffigna, Mabel MD; Belli, Susana MD; Bendezu, Karla MD; Alvarez, Silvia MD; Levalle, Oscar MD; Fainboim, Hugo MD
[Article]
Clinical & Applied Thrombosis/Hemostasis.
14(3):319-324, July 2008.
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Fatty liver represents the liver component of metabolic syndrome and may be involved in plasminogen activator inhibitor-1 (PAI-1) synthesis. We studied plasma PAI-1 levels and relationships with risk factors for metabolic syndrome, including fatty liver, in 170 patients. Liver ultrasound scan was performed on all patients, and a liver biopsy was performed on those patients with chronically elevated transaminase levels. Plasma PAI-1 levels correlated significantly (P < .05) with body mass index, degree of steatosis, insulin resistance, insulin level, waist circumference, triglycerides, and high-density lipoprotein (HDL) -cholesterol. However, only body mass index ([beta]= .455) and HDL-cholesterol ([beta] = .293) remained predictors of PAI-1 levels. Liver biopsy revealed a significant correlation (P < .05) between insulin resistance (r = 0.381) or insulin level (r = 0.519) and liver fibrosis. In patients presenting features of metabolic syndrome, plasma PAI-1 levels were mainly conditioned by the whole-body fat content.
(C)2008Sage Publications