Fusospirochetosis causing necrotic oral ulcers in patients with HIV infection.
Salama, Carlos MD a; Finch, Douglas MD b; Bottone, Edward J. PhD c; ELMHURST HOSPITAL CENTER, BRONX VETERANS ADMINISTRATION HOSPITAL, AND MOUNT SINAI SCHOOL OF MEDICINE
[Miscellaneous Article] Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, & Endodontics. 98(3):321-323, September 2004.

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Under certain permissive circumstances, normally occurring fusiform bacteria and Borrelia spirochetes can result in a symbiotic overgrowth that leads to necrotic oral ulcers (stomatitis), gingivitis, and periodontitis. These lesions are collectively known as oral fusospirochetosis and may be under-appreciated in patients with HIV infection and AIDS. Fusospirochetal oral ulcers in patients with HIV are often large, necrotic, and malodorous; they respond completely to penicillin. We report 3 patients with HIV infection and fusospirochetal ulcerative stomatitis and review the clinical presentation, microbiologic diagnosis, potential pathogenesis, and treatment of these lesions.

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