Comparing various techniques to produce micro/nanoparticles for enhancing the dissolution of celecoxib containing PVP.
Homayouni, Alireza a; Sadeghi, Fatemeh a, b; Varshosaz, Jaleh c; Garekani, Hadi Afrasiabi a, d, *; Nokhodchi, Ali e, f, *
[Article] European Journal of Pharmaceutics & Biopharmaceutics. 88(1):261-274, September 2014.

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* Concentration of PVP had a big impact on the dissolution of celecoxib particles.

* CLX nanoparticles showed improved dissolution in the presence of PVP.

* Antisolvent crystallization technique generated spherical CLX:PVP nanoparticles.

* High pressure homogenization changed the morphology of spherical nanoparticles.

* The crystallization technique had an impact on dissolution performance of celecoxib micro/nanoparticles.

(C) 2014Elsevier, Inc.