Information de reference pour ce titreAccession Number: | 00004548-200402000-00049.
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Author: | Brook, Itzhak *; Gober, Alan E.
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Institution: | Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle St. NW, Washington, DC 20016, USA
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Title: | |
Source: | Journal of Antimicrobial Chemotherapy. 53(2):399-402, February 2004.
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Abstract: | Objective: To investigate the antimicrobial susceptibility of the organisms isolated from the nasopharynx of children who present with acute maxillary sinusitis (AMS) or maxillary sinusitis that recurred (RMS) after amoxicillin therapy.
Methods: Analysis of nasopharyngeal cultures obtained from 70 patients, 42 with AMS and 28 with RMS.
Results: Thirty-eight potentially pathogenic organisms were recovered in 36 (86%) of the children from the AMS group, and 40 were isolated from 26 (93%) of the children from the RMS group. The organisms isolated were Streptococcus pneumoniae (21 isolates), Haemophilus influenzae non-type b (17), Moraxella catarrhalis (15), Streptococcus pyogenes (13) and Staphylococcus aureus (12). Resistance to the eight antimicrobial agents used was found in 34 instances in the AMS group compared to 93 instances in the RMS group (P < 0.005). The difference between AMS and RMS was significant with S. pneumoniae resistance to amoxicillin (P < 0.0025), to co-amoxiclav (P < 0.0025), to trimethoprim-sulfamethoxazole (P < 0.05), to cefixime (P < 0.05), and to azithromycin (P < 0.05), and for H. influenzae to amoxicillin (P < 0.025).
Conclusions: These data illustrate the higher recovery rate of antimicrobial-resistant S. pneumoniae and H. influenzae from the nasopharynx of children who had maxillary sinusitis that recurred after amoxicillin therapy than those with AMS.
(C) Copyright Oxford University Press 2004.
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Author Keywords: | sinusitis; Streptococcus pneumoniae; Haemophilus influenzae; Moraxella catarrhalis; antimicrobial resistance.
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References: | 1. Faden, H., Stanievich, J., Brodsky, L. et al. (1990). Changes in the nasopharyngeal flora during otitis media of childhood. Pediatric Infectious Disease 9, 623-6.
2. Dagan, R., Leibovitz, E., Cheletz, G. et al. (2001). Antibiotic treatment in acute otitis media promotes superinfection with resistant Streptococcus pneumoniae carried before initiation of treatment. Journal of Infectious Diseases 183, 880-6.
3. Brook, I., Frazier, E. H. & Foote, P. A. (1996). Microbiology of the transition from acute to chronic maxillary sinusitis. Journal of Medical Microbiology 45, 372-5.
4. Murray, P. R., Baron, E. J., Pfalter, M. A. et al. (1999). Manual of Clinical Microbiology, 7th edn. American Society for Microbiology, Washington, DC, USA.
5. National Committee for Clinical Laboratory Standards. (2000). Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically-5th Edition: Approved Standard M7-A5. NCCLS, Wayne, PA, USA.
6. Dagan, R., Abramson, O., Leibovitz, E. et al. (1996). Impaired bacteriologic response to cephalosporins in acute otitis media caused by pneumococci with intermediate resistance to penicillin. Pediatric Infectious Disease Journal 15, 980-5.
7. Brook, I. & Gober, A. E. (1999). Resistance to antimicrobials used for the therapy of otitis and sinusitis: effect of previous antimicrobial therapy and smoking. Annals of Otology, Rhinology and Laryngology 108, 645-7.
8. Ednie, L. M., Spangler, S. K., Jacobs, M. R. et al. (1997). Susceptibilities of 228 penicillin- and erythromycin-susceptible and -resistant pneumococci to RU 64004, a new ketolide, compared with susceptibilities to 16 other agents. Antimicrobial Agents and Chemotherapy 41, 1033-6.
9. Brook, I. & Gober, A. E. (1996). Prophylaxis with amoxicillin or sulfisoxazole for otitis media: effect on the recovery of penicillin-resistant bacteria from children. Clinical Infectious Diseases 22, 143-5.
10. Brook, I., Frazier, E. H. & Foote, P. A. (1997). Microbiology of chronic maxillary sinusitis: comparison between specimens obtained by sinus endoscopy and by surgical drainage. Journal of Medical Microbiology 46, 430-2.
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Language: | English.
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Document Type: | Brief report.
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Journal Subset: | Clinical Medicine. Life Sciences.
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ISSN: | 0305-7453
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NLM Journal Code: | hd7, 7513617
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