Prolonged Delayed Renal Graft Function Secondary to Venous Hypertension.
Mishra, Suraj BA 1; Gupta, Gaurav MD 1; Moinuddin, I. MD 1; Strife, Brian MD 2; Prasad, Uma MD 2; Massey, D. MD, PhD 3; King, Anne MD 1; Kumar, Dhiren MD 1; Bhati, Chandra S. MD 4
[Miscellaneous Article] Transplantation Direct. 3(10):e214, October 2017.

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The case of a 39-year-old highly sensitized woman who underwent second renal transplantation after being on warfarin because of a history of frequent thromboses of her left femoral arteriovenous graft (AVG) is reported here. The patient received a flow cytometric positive crossmatch kidney transplant from a deceased donor. Her posttransplant course was complicated by prolonged delayed graft function (DGF) lasting for 9 months. Antibody-mediated rejection occurred in the immediate postoperative period. This resolved after treatment, and resolution was confirmed by repeat biopsy. Despite this, she had persistent DGF and remained dialysis dependent. A computed tomography scan due to the development of perinephric hematoma after posttransplant biopsy demonstrated venous collateralization around the allograft. At 7 months posttransplant, a venogram during declotting of AVG revealed chronic thrombus in the inferior vena cava (IVC) above the level of native renal veins with a venous gradient of 26 mmHg. After declotting of the graft, iliac venoplasty, and subsequent IVC stent, her renal function continues to improve with a most recent creatinine of 1.4 mg/dL at 36 months posttransplant. Venous hypertension secondary to IVC thrombosis in presence of patent femoral AVG should be considered as a rare cause of prolonged DGF.

(C) 2017 The Authors. Published by Wolters Kluwer Health, Inc.