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Bottom-up modeling and simulation of tacrolimus clearance: prospective investigation of blood cell distribution, sex and CYP3A5 expression as covariates and assessment of study power.
Ohtani, Hisakazu 1; Barter, Zoe 2; Minematsu, Tsuyoshi 3; Makuuchi, Masatoshi 4; Sawada, Yasufumi 5; Rostami-Hodjegan, Amin 2,6
Biopharmaceutics & Drug Disposition.
32(9):498-506, December 2011.
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