Information de reference pour ce titreAccession Number: | 00134415-200509000-00026.
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Author: | Serjeant, Graham R. a; Hambleton, Ian b; Thame, Minerva c
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Institution: | (a)Sickle Cell Trust (Jamaica), Kingston, Jamaica (b)Tropical Medicine Research Institute, Jamaica (c)Department of Obstetrics, Gynaecology and Child Health, University of the West Indies, Jamaica
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Title: | |
Source: | BJOG: An International Journal of Obstetrics & Gynaecology. 112(9):1308-1314, September 2005.
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Abstract: | Objective: To compare pregnancy outcome in sickle cell-haemoglobin C (SC) disease with that in homozygous sickle cell (SS) disease and age-matched controls with a normal haemoglobin (AA) genotype.
Design: A cohort study followed from birth.
Setting: Sickle Cell Clinic, University Hospital and other Jamaican hospitals.
Population: Ninety-five pregnancies in 43 patients with SC disease, 94 pregnancies in 52 patients with SS disease and 157 pregnancies in 68 controls.
Methods: Systematic review of all pregnancies occurring in sample population. Kaplan-Meier analysis for interval to first pregnancy, and the t test, [chi]2 test or Fisher's exact test as appropriate; correction was made for multiple testing and multiple linear regression was used for analysis of determinants of birthweight.
Main outcome measures: Age at menarche, interval to first pregnancy, outcome of pregnancy, maternal complications and possible predictors of low birthweight.
Results: Menarche was marginally delayed in SC disease compared with AA controls (median age 13.7 vs 13.0 years, P= 0.02) but age at first pregnancy was similar (median age 22.5 vs 20.1 years, P= 0.32). Pregnancy outcome in SC disease did not differ from AA controls but compared with SS disease there were marginally fewer miscarriages, more live deliveries and greater birthweight. The prevalence of pregnancy-induced hypertension, pre-eclampsia, antepartum or postpartum haemorrhage in SC disease did not differ from AA controls but the prevalence of sickle-related complications was similar to SS disease.
Conclusions: Contrary to some claims, pregnancy outcome in SC disease is generally benign compared with SS disease.
Copyright (C) 2005 Blackwell Publishing Ltd.
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References: | 1. Smith EW, Conley CL. Clinical features of the genetic variants of sickle cell disease. Bull Johns Hopkins Hosp 1954;94: 289-318.
2. Horger EO. Sickle cell and sickle cell-hemoglobin C disease during pregnancy. Obstet Gynecol 1972;39: 873-879.
3. Kaplan E, Zuelzer WW, Neel JV. Further studies on hemoglobin C. II: The hematologic effects of hemoglobin C alone and in combination with sickle cell hemoglobin. Blood 1953;8: 735-746.
4. Chernoff AI. The human hemoglobins in health and disease. N Engl J Med 1955;253: 322-331, 365-374, 416-423.
5. Molina V, Marks S. Sickle cell disease in pregnancy, with electrophoresis in twenty-two cases. Bull Tulane Univ Med Fac 1957;17: 19-30.
6. Abrams J, Schwartz IR. The sickle cell diseases in pregnancy. Am J Obstet Gynecol 1959;77: 1324-1327.
7. Curtis EM. Pregnancy in sickle cell anemia, sickle cell-hemoglobin C disease, and variants thereof. Am J Obstet Gynecol 1959;77: 1312-1323.
8. Tuck SM, Studd JWW, White JM. Pregnancy in sickle cell disease in the UK. Br J Obstet Gynaecol 1983;90: 112-117.
9. Serjeant GR, Look Loy L, Crowther M, Hambleton IR, Thame M. Outcome of pregnancy in homozygous sickle cell disease. Obstet Gynecol 2004;103: 1278-1285.
10. Serjeant BE, Forbes M, Williams LL, Serjeant GR. Screening cord bloods for detection of sickle cell disease. Clin Chem 1974;20: 666-669.
11. Serjeant GR, Serjeant BE, Forbes M, Hayes RJ, Higgs DR, Lehmann H. Haemoglobin gene frequencies in the Jamaican population: a study of 100,000 newborns. Br J Haematol 1986;64: 253-262.
12. Betke K, Marti HR, Schlicht I. Estimation of small percentages of foetal haemoglobin. Nature 1959;184: 1877-1878.
13. Gifford Jr RW, August PA, Cunningham G, et al. Report of the National High Blood Pressure Education Program Working Group on high blood pressure in pregnancy. Am J Obstet Gynecol 2000;183: S1-S22.
14. White H. Maximum likelihood estimation of misspecified models. Econometrica 1982;50: 1-25.
15. Serjeant GR, Singhal A, Hambleton IR. Sickle cell disease and age at menarche in Jamaican girls: observations from a cohort study. Arch Dis Child 2001;85: 375-378.
16. Serjeant GR, Serjeant BE. The eyes, Chapter 21 in Sickle Cell Disease, 3rd edition. Oxford: Oxford University Press,2001: 366-392.
17. Wyatt JP, Orrahood MD. Massive fat embolism following marrow infarction in sickle cell anemia. Arch Pathol 1952;53: 233-238.
18. Shelley WM, Curtis EM. Bone marrow and fat embolism in sickle cell anemia and sickle cell-hemoglobin C disease. Bull Johns Hopkins Hosp 1958;103: 8-25.
19. Rywlin AM, Block AL, Werner CS. Hemoglobin C and S in pregnancy. Am J Obstet Gynecol 1963;86: 1055-1059.
20. Chmel H, Bertles JF. Hemoglobin S/C disease in a pregnant woman with crisis and fat embolization syndrome. Am J Med 1975;58: 563-566.
21. Hendrickse JPdeV, Watson-Williams EJ. The influence of hemoglobinopathies on reproduction. Am J Obstet Gynecol 1966;94: 739-748.
22. Smith JA, Espeland M, Bellevue R, Bonds D, Broan AK, Koshy M. Pregnancy in sickle cell disease: experience of the cooperative study of sickle cell disease. Obstet Gynecol 1996;87: 199-204.
23. Milner PF, Jones BR, Dobler J. Outcome of pregnancy in sickle cell anemia and sickle cell-hemoglobin C disease. Am J Obstet Gynecol 1980;138: 239-245.
24. Fort AT, Morrison JC, Barreras L, Diggs LW, Fish SA. Counseling the patient with sickle cell disease about reproduction: pregnancy outcome does not justify the maternal risk!! Am J Obstet Gynecol 1971;111: 324-327.
25. Pritchard JA, Scott DE, Whalley PJ, Cunningham FG, Mason RA. The effects of maternal sickle cell hemoglobinopathies and sickle cell trait on reproductive performance. Am J Obstet Gynecol 1973;117: 662-670.
26. Anderson MF. The foetal risks in sickle cell anaemia. West Indian Med J 1971;20: 288-295.
27. McCurdy PR. Abnormal hemoglobins and pregnancy. Am J Obstet Gynecol 1964;90: 891-896.
28. Hendrickse JPdeV, Harrison KA, Watson-Williams EJ, Luzzatto L, Ajabor LN. Pregnancy in homozygous sickle-cell anaemia. J Obstet Gynaecol Br Commomw 1972;79: 396-409.
29. Charache S, Scott J, Niebyl J, Bonds D. Management of sickle cell disease in pregnant patients. Obstet Gynecol 1980;55: 407-410.
30. Powars DR, Sandhu M, Niland-Weiss J, Johnson C, Bruce S, Manning PR. Pregnancy in sickle cell disease. Obstet Gynecol 1986;67: 217-228.
31. Dare FO, Makinde OO, Faasuba OB. The obstetric performance of sickle cell disease patients and homozygous hemoglobin C patients in Ile-Ife, Nigeria. Int J Gynecol Obstet 1992;37: 163-168.
32. Seoud MA-F, Cantwell C, Nobles G, Levy DL. Outcome of pregnancies complicated by sickle cell and sickle-C hemoglobinopathies. Am J Perinatol 1994;11: 187-191.
33. Mou Sun P, Wilburn W, Raynor BD, Jamieson D. Sickle cell disease in pregnancy: twenty years of experience at Grady Memorial Hospital, Atlanta, Georgia. Am J Obstet Gynecol 2001;184: 1127-1130.
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Language: | English.
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Document Type: | GENERAL OBSTETRIC.
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Journal Subset: | Clinical Medicine.
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ISSN: | 1470-0328
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NLM Journal Code: | 100935741
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