Synthesis of novel mesoporous silica nanoparticles for loading and release of ibuprofen.
Zhang, Haijiao; Li, Zhiyong; Xu, Panpan; Wu, Ruofei; Wang, Lin; Xiang, Yuewen; Jiao, Zheng
[Article] Journal of Controlled Release. 152 Supplement 1:e38-e39, November 2011.

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summary: Mesoporous silica nanoparticles (MSNs) with unique structure were synthesized under mild conditions by a facile two-step method in the presence of ethyl ether. Ibuprofen as a common anti-inflammatory and analgesic drug was used to evaluate the MSNs' controlled drug release properties. The results indicated that the prepared MSNs exhibited a large loading content and excellent release rate, attaining as high as 96.3% drug release in 3 h.

(C) 2011Elsevier, Inc.