Information de reference pour ce titreAccession Number: | 00006450-200911000-00015.
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Author: | SABIROV, ALBERT; CASEY, JANET R.; MURPHY, TIMOTHY F.; PICHICHERO, MICHAEL E.
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Institution: | Department of Microbiology/Immunology [A.S.], University of Rochester, Rochester, New York 14627; Department of Pediatrics [J.R.C.], Legacy Pediatrics, Rochester, New York 14618; Department of Medicine [T.F.M.], State University of New York at Buffalo, Buffalo, New York 14260; Department of Immunology and Center for Infectious Disease [M.E.P.], Rochester General Hospital Research Institute, Rochester, New York 14621
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Title: | Breast-Feeding Is Associated With a Reduced Frequency of Acute Otitis Media and High Serum Antibody Levels Against NTHi and Outer Membrane Protein Vaccine Antigen Candidate P6.[Article]
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Source: | Pediatric Research. 66(5):565-570, November 2009.
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Abstract: | Nontypeable Haemophilus influenzae (NTHi) causes acute otitis media (AOM) in infants. Breast-feeding protects against AOM and/or nasopharyngeal (NP) colonization; however, the mechanism of protection is incompletely understood. Children with AOM and healthy children were studied according to feeding status: breast-fed, breast/formula fed, or formula fed. Cumulative episodes of AOM, ELISA titers of serum IgG antibodies to whole-cell NTHi and vaccine candidate outer membrane protein P6, bactericidal titers of serum and NP colonization by NTHi were assessed. A lower incidence of AOM was found in breast- versus formula-fed children. Levels of specific serum IgG antibody to NTHi and P6 were highest in breast-fed, intermediate in breast/formula fed, and lowest in formula-fed infants. Serum IgG antibody to P6 correlated with bactericidal activity against NTHi. Among children with AOM, the prevalence of NTHi in the NP was lower in breast- versus nonbreast-fed infants. We conclude that breast-feeding shows an association with higher levels of antibodies to NTHi and P6, suggesting that breast-feeding modulates the serum immune response to NTHi and P6. Higher serum IgG might facilitate protection against AOM and NP colonization in breast-fed children.
(C) International Pediatrics Research Foundation, Inc. 2009. All Rights Reserved.
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Language: | English.
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Document Type: | Articles: Clinical Investigation.
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Journal Subset: | Clinical Medicine. Life Sciences.
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ISSN: | 0031-3998
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NLM Journal Code: | owl, 0100714
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DOI Number: | https://dx.doi.org/10.1203/PDR.0...- ouverture dans une nouvelle fenêtre
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