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mdash;: Baseline CSF amyloid [beta]-peptide-42 (A[beta]42), tau, and phosphorylated tau (P-tau) levels from 46 control subjects and 78 patients with mild cognitive impairment (MCI) were measured. Twenty-three patients with MCI developed dementia during the study. Abnormal biomarkers were found early in the course of Alzheimer disease (AD). The most predictive assay for AD among the patients with MCI was the combination of A[beta]42 and P-tau.

(C) 2005 American Academy of Neurology