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A Double-Blinded Prospective Evaluation of Recombinant Human Erythropoietin in Acutely Burned Patients.
Still, Joseph M. Jr, MD; Belcher, Keith PhD; Law, Edward J. MD; Thompson, William PhD; Jordan, Marion MD; Lewis, Mark MS, RRT; Saffle, Jeffrey MD; Hunt, John MD; Purdue, Gary F. MD; Waymack, J. Paul MD; DeClement, Frederick MD; Kagan, Richard MD; Chen, Andrew MSc
Journal of Trauma-Injury Infection & Critical Care.
38(2):233-236, February 1995.
Objective: To evaluate the effects of recombinant human erythropoietin (r-HuEPO) in attempting to prevent anemia in acutely burned patients.
Design: Prospective double-blined randomized study of 40 patients.
Methods: Patients with burns from 25% to 65% total body surface were enrolled. r-HuEPO or a placebo was begun within 72 hours of admission. Cell blood count, reticulocyte counts, tranfusion requirements, and blood loss were measured. Comparison was carried out by the unpaired t test.
Main Results: There was no statistically significant difference in hemoglobin, hematocrit, reticlocyte count, ferritin, serum iron, total iron blinding capacity, or transfusion requirements. In patients with burns from 25% to 35%, the reticulocyte counts were statistically significantly higher.
Conclusion: In our work the administation of r-HuEPO in acutely burned patients did not prevent the development of postburn anemia or decresase transfusion requirements. Increased erythropoiesis in smaller burns (25% to 35%) was observed and may indicate a reason for further study.
(C) Williams & Wilkins 1995. All Rights Reserved.