Chronic endothelin receptor antagonist treatment of young spontaneously hypertensive rats.
Li, Jin-S; Schiffrin, Ernesto L.
[Article]
Journal of Hypertension.
13(6):647-652, June 1995.
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Objective: The effect of the combined ETA/ETBendothelin receptor antagonist bosentan was evaluated in 4-week-old spontaneously hypertensive rats (SHR) and control Wistar-Kyoto (WKY) rats, which were treated for 10 weeks, to determine whether endothelins were involved in the development of hypertension or cardiovascular remodeling in young SHR.
Methods: Four-week-old SHR and WKY rats received bosentan 100mg/kg per day mixed with their food. Blood pressure was measured by the tail-cuff method every 2 weeks. At 14 weeks of age the coronary, renal, mesenteric and femoral small arteries were examined on a wire myograph.
Results: The blood pressure both of SHR and of WKY rats was identical in bosentan-treated and untreated rats throughout the study. The media width, lumen diameter, media width: lumen diameter ratio and media cross-sectional area of small arteries of the four vascular beds examined were similar in bosentan-treated and untreated SHR, as were the wet weights of aorta segments and the mesenteric vascular bed.
Conclusion: Endothelins are not involved in the development of hypertension or vascular hypertrophy and remodelling in young SHR.
(C) Lippincott-Raven Publishers.