Information de reference pour ce titreAccession Number: | 00003656-200308080-00011.
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Author: | Kelly, Sara; Chapman, Victoria *
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Institution: | School of Biomedical Sciences, University of Nottingham Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, UK
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Title: | |
Source: | European Journal of Pharmacology. 474(2):209-216, August 2003.
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Abstract: | : Spinally administered cannabinoid receptor agonists are anti-nociceptive in a variety of models of acute and persistent pain. The present study investigated the effects of activation of spinal cannabinoid CB1 receptors on mechanically evoked responses of spinal neurones in acute and inflammatory pain states. In vivo electrophysiology studies were carried out in anaesthetised rats. Effects of spinal administration of a selective cannabinoid CB1 receptor agonist, arachidonyl-2-chloroethylamide (ACEA), on mechanically evoked responses of dorsal horn neurones in control rats and rats with peripheral hindpaw carrageenan-induced inflammation were compared. ACEA (0.27 nM-27 [mu]M) significantly inhibited innocuous and noxious mechanically evoked responses of dorsal horn neurones in control rats. Pre-administration of the CB1 receptor antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1(2,4-dichlorophenyl)-4-methyl-1-H-pyrazole-3-carboxyamide, SR141716A, (0.43 [mu]M) attenuated the inhibitory effects of ACEA (27 [mu]M). ACEA did not alter mechanically evoked responses of dorsal horn neurones in rats with hindpaw carrageenan-induced inflammation. Following peripheral inflammation, there is a loss of spinal CB1 receptor-mediated inhibition of mechanically evoked responses, which is suggestive of a functional down-regulation of CB1 receptors under these conditions.
(C) 2003Elsevier, Inc.
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Author Keywords: | Spinal cord; Cannabinoid CB1 receptor; Carrageenan inflammation; von Frey monofilament; Dorsal horn neurone; Cannabinoid CB1 receptor agonist; selective.
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Language: | English.
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Document Type: | Articles.
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Journal Subset: | Pharmacology.
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ISSN: | 0014-2999
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NLM Journal Code: | en6, 1254354
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DOI Number: | https://dx.doi.org/10.1016/S0014...- ouverture dans une nouvelle fenêtre
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