Information de reference pour ce titreAccession Number: | 00000595-200807000-00010.
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Author: | Sureda, Antoni a; Tauler, Pedro a; Aguilo, Antoni a; Cases, Nuria a; Llompart, Isabel b; Tur, Josep A. a; Pons, Antoni a
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Institution: | (a)Laboratori de Ciencies de l'Activitat Fisica, Departament de Biologia Fonamental i Ciencies de la Salut, Universitat de les Illes Balears, and (b)Laboratori del Carme, Hospital Son Dureta, INSALUD, Palma de Mallorca, Spain
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Title: | |
Source: | Annals of Nutrition & Metabolism. 52(3):233-240, July 2008.
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Abstract: | Background/Aims: Our aim was to determine whether the consumption of a functional drink enriched with vitamin C and vitamin E could alleviate exercise-induced oxidative damage in lymphocytes.
Methods: Fourteen male amateur trained runners (32-36 years old) were randomized to receive antioxidant supplementation (152 mg vitamin C/day and 50 mg vitamin E/day) or placebo for 1 month in a double-blind study, and participated in a half-marathon race. The volunteers did not take any other antioxidant supplements. Blood samples were taken before and after the half-marathon and after 3 h recovery.
Results: Exercise increased lymphocyte malondialdehyde levels only in the placebo group (p < 0.001). Lymphocytes from the supplemented group accumulated more vitamin C and vitamin E than placebo after exercise and recovery (p < 0.05). Catalase and glutathione peroxidase activities increased only in the supplemented group after exercise, whereas superoxide dismutase activity increased in both groups (p < 0.05). Heme oxygenase-1 expression was enhanced during the recovery period only in the placebo group (p < 0.01). Bcl-2 expression decreased after exercise only in the placebo group and remained low during the recovery (p < 0.001).
Conclusions: Intense exercise increases lipid peroxidation, decreases Bcl-2 expression and induces an antioxidant response in lymphocytes. Supplementation with moderate levels of antioxidant vitamins reduces exercise-induced oxidative damage, but without blocking the cellular adaptation to exercise.
(C) 2008 S. Karger AG, Basel
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Author Keywords: | Oxidative stress; Antioxidant vitamins; Exercise; Lymphocytes; Heme oxygenase-1.
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Language: | English.
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Document Type: | Original Paper.
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Journal Subset: | Clinical Medicine.
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ISSN: | 0250-6807
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NLM Journal Code: | 58e, 8105511
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