Idiopathic Thrombocytopenic Purpura (ITP) in Children.
Baronci, Carlo MD 1; Pansini, Valeria MD 1; Funaro, Daria MD 1; Coletti, Valentina MD 1; Caruso, Roberta MD 1; De Rossi, Giulio MD 1,*
[Review]
Pediatric Blood & Cancer.
47 Supp 5:665-667, October 15, 2006.
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: Idiopathic thrombocytopenic purpura in children remits spontaneously in the majority of cases but most children require treatment. Between 1995 and 2005, 265 children (0-15 years old) have been consecutively observed and treated: 28 children with high doses of methylprednisolone (HDMP) (15 mg/kg x 4 days), 63 with HDMP (7.5 mg/kg x 4 days), 37 with HD dexamethasone (DXM) pulses, 29 with low doses of MP, and 51 with different doses of intravenous immunoglobulins (IVIG) (0.4 or 0.8 g/kg). Fifty-seven children have not been treated because of a platelet count >=10 x 109/L and no significant bleeding. Two hundred forty-four (92.1%) children reached a persistent CR, 237 (89.4%) after a first-line treatment or the wait and see strategy. No statistically significant differences in CR related to different treatments have been observed. IVIG and HDMP (7.5 mg/kg for 4 days) are the best treatments to reach quickly safe platelet levels >=30 x 109/L (3-6 days) and CR (7-11 days). Among non-responding (NR) patients, seven have been splenectomized and three reached stable CR. These results emphasize differences with adult ITP. Pediatr Blood Cancer 2006;47:665-667. (C) 2006 Wiley-Liss, Inc.
Copyright (C) 2006 John Wiley & Sons, Inc.