Chromosome 9p21 primary open-angle glaucoma susceptibility locus: a review.
Ng, Soo Khai MBBS 1,2; Casson, Robert J DPhil FRANZCO 1,2; Burdon, Kathryn P PhD 3; Craig, Jamie E DPhil FRANZCO 3
[Review]
Clinical & Experimental Ophthalmology.
42(1):25-32, January/February 2014.
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Primary open-angle glaucoma (POAG) is a genetically complex disease. Genome-wide association study (GWAS) is a particularly useful tool in the search for genetic contributions to glaucoma. Recently, chromosome 9p21 has become a major focus of research endeavour, with multiple genome-wide association studies suggesting associations to POAG. Herein, we provide a review of the chromosome 9p21 susceptibility locus as a risk factor for POAG.
(C) 2014 John Wiley & Sons, Ltd
