Hepatocellular carcinoma in a liver-cell adenoma within a non-cirrhotic liver.
Burri, Emanuel a; Steuerwald, Michael a; Cathomas, Gieri a; Mentha, Gilles b; Majno, Pietro b; Rubbia-Brandt, Laura b; Meier, Re[spacing acute]my a
European Journal of Gastroenterology & Hepatology.
18(4):437-441, April 2006.
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Liver-cell adenomas are benign lesions of the liver occurring predominantly in young women. Hepatocellular carcinomas in most of the cases arise in a cirrhotic liver during the fifth or sixth decade. We describe the case of a 40-year-old woman in whom work-up for epigastric pain revealed a peptic ulcer and a large hepatic mass. Tests for chronic liver diseases were negative. Imaging findings and biopsy specimens of the tumour were inconclusive. The tumour was surgically removed and a hepatocellular carcinoma arising within a liver-cell adenoma in a non-cirrhotic liver was found. Malignant transformation of liver-cell adenoma has only been reported in a few case reports. Mechanisms of transformation remain unclear. The imaging findings as well as histological features are presented in detail and the literature is discussed.
(C) 2006 Lippincott Williams & Wilkins, Inc.