Genome-wide scan for Parkinson's disease:: The Gene PD Study.
DeStefano, A. L. PhD; Golbe, L. I. MD; Mark, M. H. MD; Lazzarini, A. M. PhD; Maher, N. E. MPH; Saint-Hilaire, M. MD; Feldman, R. G. MD; Guttman, M. MD; Watts, R. L. MD; Suchowersky, O. MD; Lafontaine, A. L. MD; Labelle, N. BS; Lew, M. F. MD; Waters, C. H. MD; Growdon, J. H. MD; Singer, C. MD; Currie, L. J. PhD; Wooten, G. F. MD; Vieregge, P. MD; Pramstaller, P. P. MD; Klein, C. MD; Hubble, J. P. MD; Stacy, M. MD; Montgomery, E. MD; MacDonald, M. E. PhD; Gusella, J. F. PhD; Myers, R. H. PhD
57(6):1124-1126, September 25, 2001.
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Article abstract-: A genome-wide scan for idiopathic PD in a sample of 113 PD-affected sibling pairs is reported. Suggestive evidence for linkage was found for chromosomes 1 (214 cM, lod = 1.20), 9 (136 cM, lod = 1.30), 10 (88 cM, lod = 1.07), and 16 (114 cM, lod = 0.93). The chromosome 9 region overlaps the genes for dopamine [beta]-hydroxylase and torsion dystonia. Although no strong evidence for linkage was found for any locus, these results may be of value in comparison with similar studies by others.
(C) 2001 American Academy of Neurology