T cells from patients with Parkinson's disease recognize [alpha]-synuclein peptides.
Sulzer, David 1,2,3; Alcalay, Roy N. 2; Garretti, Francesca 1; Cote, Lucien 2; Kanter, Ellen 1; Agin-Liebes, Julian 1; Liong, Christopher 2; McMurtrey, Curtis 4; Hildebrand, William H. 4; Mao, Xiaobo 5,6; Dawson, Valina L. 5,6,7,8; Dawson, Ted M. 5,6,8,9; Oseroff, Carla 10; Pham, John 10; Sidney, John 10; Dillon, Myles B. 10; Carpenter, Chelsea 10; Weiskopf, Daniela 10; Phillips, Elizabeth 11,1,2; Mallal, Simon 11,1,2; Peters, Bjoern 10; Frazier, April 10; Arlehamn, Cecilia S. Lindestam 10; Sette, Alessandro 10
[Letter]
Nature.
546(7660):656-661, June 29, 2017.
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: Epitopes derived from two regions of [alpha]-synuclein elicit immune responses in patients with Parkinson's disease, involving IL-5-secreting CD4 T cells, as well as IFN[gamma]-secreting CD8 cytotoxic T cells.
Genetic studies have shown the association of Parkinson's disease with alleles of the major histocompatibility complex 1,2,3. Here we show that a defined set of peptides that are derived from [alpha]-synuclein, a protein aggregated in Parkinson's disease 4, act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson's disease. These responses may explain the association of Parkinson's disease with specific major histocompatibility complex alleles.
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