Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor.
Horlein, Andreas J.; Naar, Anders M.; Heinzel, Thorsten; Torchia, Joseph; Gloss, Bernd; Kurokawa, Riki; Ryan, Aimee; Kamei, Yasutomi; Soderstrom, Mats; Glass, Christopher K.; Rosenfeld, Michael G.
[Article] Nature. 377(6548):397-404, October 5, 1995.

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Thyroid-hormone and retinoic-acid receptors exert their regulatory functions by acting as both activators and repressors of gene expression. A nuclear receptor co-repressor (N-CoR) of relative molecular mass 270K has been identified which mediates ligand-independent inhibition of gene transcription by these receptors, suggesting that the molecular mechanisms of repression by thyroid-hormone and retinoic-acid receptors are analogous to the co-repressor-dependent transcriptional inhibitory mechanisms of yeast and Drosophila.

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