Information de reference pour ce titreAccession Number: | 00004686-200808000-00033.
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Author: | Asahi, Atsuko 1,2; Nishimoto, Tetsuya 1; Okazaki, Yuka 1; Suzuki, Hidekazu 3; Masaoka, Tatsuhiro 3; Kawakami, Yutaka 4; Ikeda, Yasuo 2; Kuwana, Masataka 1
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Institution: | (1)Division of Rheumatology, (2)Division of Hematology, and (3)Division of Gastroenterology and Hepatology, Department of Internal Medicine, and (4)Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.
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Title: | Helicobacter pylori eradication shifts monocyte Fc[gamma] receptor balance toward inhibitory Fc[gamma]RIIB in immune thrombocytopenic purpura patients.[Article]
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Source: | Journal of Clinical Investigation. 118(8):2939-2949, August 2008.
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Abstract: | Immune thrombocytopenia purpura (ITP) is a bleeding disorder in which platelet-specific autoantibodies cause a loss of platelets. In a subset of patients with ITP and infected with Helicobacter pylori, the number of platelets recovers after eradication of H. pylori. To examine the role of H. pylori infection in the pathogenesis of ITP, the response of 34 ITP patients to treatment with a standard H. pylori eradication regimen, irrespective of whether they were infected with H. pylori, was evaluated. Eradication of H. pylori was achieved in all H. pylori-positive patients, and a significant increase in platelets was observed in 61% of these patients. By contrast, none of the H. pylori-negative patients showed increased platelets. At baseline, monocytes from the H. pylori-positive patients exhibited an enhanced phagocytic capacity and low levels of the inhibitory Fc[gamma] receptor IIB (Fc[gamma]RIIB). One week after starting the H. pylori eradication regimen, this activated monocyte phenotype was suppressed and improvements in autoimmune and platelet kinetic parameters followed. Modulation of monocyte Fc[gamma]R balance was also found in association with H. pylori infection in individuals who did not have ITP and in mice. Our findings strongly suggest that the recovery in platelet numbers observed in ITP patients after H. pylori eradication is mediated through a change in Fc[gamma]R balance toward the inhibitory Fc[gamma]RIIB.
Copyright (C) 2008 The American Society for Clinical Investigation, Inc.
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Language: | English.
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Document Type: | Research Article.
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Journal Subset: | Clinical Medicine. Life Sciences.
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ISSN: | 0021-9738
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NLM Journal Code: | hs7, 7802877
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