Haemodialysis for the Prevention of Contrast-Induced Nephropathy: Outcome of 31 Patients With Severely Impaired Renal Function, Comparison With Patients at Similar Risk and Review.
HUBER, WOLFGANG MD *; JESCHKE, BARBARA MD *; KREYMANN, BERNHARD MD *; HENNIG, MICHAEL +; PAGE, MICHAEL PhD ++; SALMHOFER, HERMANN MD *; ECKEL, FLORIAN MD *; SCHMIDT, ULRIKE MD *; UMGELTER, ANDREAS MD *; SCHWEIGART, URSULA MD *; CLASSEN, MEINHARD MD *
[Article] Investigative Radiology. 37(9):471-481, September 2002.

(Format: HTML, PDF)

Huber W, Jeschke B, Kreymann B, et al. Haemodialysis for the prevention of contrast-induced nephropathy. Outcome of 31 patients with severely impaired renal function, comparison with patients at similar risk and review. Invest Radiol 2002;37:471-481.

Rationale and Objectives. To investigate whether haemodialysis prevents contrast-induced nephropathy (definition: increase of serum-creatinine of >= 0.5 mg/dL within 7 days).

Materials and Methods. Thirty-one patients (mean serum-creatinine 4.01 /- 1.83 mg/dL) were dialyzed for 4.36 /- 1.0 hours within one hour after 278.4 /- 160.5 mL of contrast medium.

Results. Dialysis resulted in a significant reduction of serum-creatinine (2.25 /- 1.46 mg/dL;P < 0.0001) and stable mean serum-creatinine levels 2, 3, 4, and 7 days after contrast medium and at discharge compared with baseline values. However, 19 patients (61%) developed contrast-induced nephropathy within 7 days. Four patients had to be repeatedly dialyzed. A comparison of our patients' 48 hours-incidence of contrast-induced nephropathy (9/31; 29%) versus patients at comparable risk included in seven previous studies demonstrated a prophylactic effect of dialysis only versus a subgroup in one study.

Conclusions. Data provide no hint that haemodialysis prevents contrast-induced nephropathy. Therefore, postprocedural dialysis should be restricted to patients participating in clinical studies.

(C) 2002 Lippincott Williams & Wilkins, Inc.