Evaluation of an Electrochemical Sensor for Measuring Blood Ketones.
Byrne, Hilary A. MRCP; Tieszen, Kenneth L. PHD; Hollis, Sally MSC; Dornan, Tim L. FRCP; New, John P. MRCP
[Article]
Diabetes Care.
23(4):500-503, April 2000.
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OBJECTIVE: To evaluate the performance of a hand-held ketone sensor that is able to measure blood [beta]-hydroxybutyrate ([beta]-HBA) concentrations within 30 s in patients with diabetic ketoacidosis (DKA) and patients who attend a weight management clinic.
RESEARCH DESIGN AND METHODS: Two groups of patients were studied: 19 patients admitted with DKA and 156 patients attending a weight management clinic. Paired capillary and venous whole blood samples were measured using the ketone sensor and also using an enzymatic laboratory reference method.
RESULTS: The ketone sensor accurately measured [beta]-HBA concentrations in patients with DKA (limits of agreement -0.9 to 1.0 mmol/l) or starvation-induced ketonemia (limits of agreement -0.5 to 0.5 mmol/l).
CONCLUSIONS: This ketone sensor accurately measures whole blood [beta]-HBA concentrations within 30 s.
(C) 2000 by the American Diabetes Association, Inc.