Nonnecrobiotic Necrobiotic Xanthogranuloma as an Initial Manifestation of Paraproteinemia and Small Lymphocytic Lymphoma in a Patient With Sjogren Syndrome.
Naghashpour, Mojdeh MD, PhD *; Setoodeh, Reza MD +; Moscinski, Lynn MD ++; Bergier, Gregoire MD [S]; McCardle, Timothy MD; Glass, Frank MD ||; Sokol, Lubomir MD, PhD [P]
American Journal of Dermatopathology.
33(8):855-857, December 2011.
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We report a unique case of periocular nonnecrobiotic necrobiotic xanthogranuloma in a 52-year-old white woman with Sjogren syndrome who was subsequently found to have an immunoglobulin G paraproteinemia and coexisting small lymphocytic lymphoma. Therapy with fludarabine, cytoxan, and rituximab (FCR) resulted in a dramatic resolution of her sicca symptoms and periocular xanthogranulomas. This case further illustrates the association of hematolymphoid disorders with cutaneous xanthogranulomatous disease and the importance of additional appropriate laboratory and radiologic investigation for the accurate diagnosis of an underlying malignancy.
(C) 2011 Lippincott Williams & Wilkins, Inc.