Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease.
Balducci, Chiara PhD 1; Pierguidi, Laura MD 2,3; Persichetti, Emanuele PhD 1; Parnetti, Lucilla MD 2; Sbaragli, Michele PhD 1; Tassi, Carmelo PhD 4; Orlacchio, Aldo PhD 4; Calabresi, Paolo MD 2,3; Beccari, Tommaso PhD 1,*; Rossi, Aroldo MD 2
[Report] Movement Disorders. 22(10):1481-1484, July 30, 2007.

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colon; Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of [beta]-glucocerebrosidase and the activities of other lysosomal enzymes, [alpha]-mannosidase, [beta]-mannosidase, [beta]-hexosaminidase, and [beta]-galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of [alpha]-mannosidase, [beta]-mannosidase, [beta]-glucocerebrosidase, and [beta]-hexosaminidase were substantially decreased in the CSF of PD patients, while levels of [beta]-galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases.

Copyright (C) 2007 John Wiley & Sons, Inc.