Defining the optimal dose of a new drug: a crucial decision.
Heerspink, Hiddo Lambers; de Zeeuw, Dick
[Miscellaneous] Nature Reviews Nephrology. 5(9):498-500, September 2009.

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: Defining the dose of a new renoprotective drug with the optimal benefit-to-risk ratio is an important consideration for drug developers and physicians. Have we learned from past experiences?

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