Information de reference pour ce titreAccession Number: | 00007529-201308160-00009.
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Author: | Carpenter, Susan 1,2; Aiello, Daniel 1; Atianand, Maninjay K. 1; Ricci, Emiliano P. 3; Gandhi, Pallavi 1; Hall, Lisa L. 4; Byron, Meg 4; Monks, Brian 1; Henry-Bezy, Meabh 1; Lawrence, Jeanne B. 4; O'Neill, Luke A. J. 2; Moore, Melissa J. 3; Caffrey, Daniel R. 1*+; Fitzgerald, Katherine A. 1*+
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Institution: | (1)Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. (2)School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland. (3)Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA. (4)Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
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Title: | |
Source: | Science. 341(6147):789-792, August 16, 2013.
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Abstract: | : An inducible program of inflammatory gene expression is central to antimicrobial defenses. This response is controlled by a collaboration involving signal-dependent activation of transcription factors, transcriptional co-regulators, and chromatin-modifying factors. We have identified a long noncoding RNA (IncRNA) that acts as a key regulator of this inflammatory response. Pattern recognition receptors such as the Toll-like receptors induce the expression of numerous IncRNAs. One of these, lincRNA-Cox2, mediates both the activation and repression of distinct classes of immune genes. Transcriptional repression of target genes is dependent on interactions of lincRNA-Cox2 with heterogeneous nuclear ribonucleoprotein A/B and A2/B1. Collectively, these studies unveil a central role of lincRNA-Cox2 as a broad-acting regulatory component of the circuit that controls the inflammatory response.
Copyright (C) 2013 by the American Association for the Advancement of Science
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Language: | English.
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Document Type: | REPORTS.
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Journal Subset: | Life Sciences. Physical Science & Engineering.
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ISSN: | 0036-8075
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NLM Journal Code: | 0404511, uj7
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DOI Number: | https://dx.doi.org/10.1126/scien...- ouverture dans une nouvelle fenêtre
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