Information de reference pour ce titreAccession Number: | 00006056-201405220-00038.
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Author: | Pascoli, Vincent 1, *; Terrier, Jean 1, *; Espallergues, Julie 2, 3, 4; Valjent, Emmanuel 2, 3, 4; O'Connor, Eoin Cornelius 1; Luscher, Christian 1, 5, #
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Institution: | (1) Department of Basic Neurosciences, Medical Faculty, University of Geneva, CH-1211 Geneva, Switzerland (2) INSERM, U661, Montpellier F-34094, France (3) CNRS, UMR-5203, Institut de Genomique Fonctionnelle, Montpellier F-34094, France (4) Universites de Montpellier 1 & 2, UMR-5203, Montpellier F-34094, France (5) Clinic of Neurology, Department of Clinical Neurosciences, Geneva University Hospital, CH-1211 Geneva, Switzerland (*)These authors contributed equally to this work.
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Title: | Contrasting forms of cocaine-evoked plasticity control components of relapse.[Article]
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Source: | Nature. 509(7501):459-464, May 22, 2014.
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Abstract: | : Nucleus accumbens neurons serve to integrate information from cortical and limbic regions to direct behaviour. Addictive drugs are proposed to hijack this system, enabling drug-associated cues to trigger relapse to drug seeking. However, the connections affected and proof of causality remain to be established. Here we use a mouse model of delayed cue-associated cocaine seeking with ex vivo electrophysiology in optogenetically delineated circuits. We find that seeking correlates with rectifying AMPA ([alpha]-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptor transmission and a reduced AMPA/NMDA (N-methyl-d-aspartate) ratio at medial prefrontal cortex (mPFC) to nucleus accumbens shell D1-receptor medium-sized spiny neurons (D1R-MSNs). In contrast, the AMPA/NMDA ratio increases at ventral hippocampus to D1R-MSNs. Optogenetic reversal of cocaine-evoked plasticity at both inputs abolishes seeking, whereas selective reversal at mPFC or ventral hippocampus synapses impairs response discrimination or reduces response vigour during seeking, respectively. Taken together, we describe how information integration in the nucleus accumbens is commandeered by cocaine at discrete synapses to allow relapse. Our approach holds promise for identifying synaptic causalities in other behavioural disorders.
(C) 2014 Nature Publishing Group
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Language: | English.
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Document Type: | ARTICLE.
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Journal Subset: | Life & Biomedical Sciences. Science.
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ISSN: | 0028-0836
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NLM Journal Code: | 0410462, nsc
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DOI Number: | https://dx.doi.org/10.1038/natur...- ouverture dans une nouvelle fenêtre
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