A call for transparent reporting to optimize the predictive value of preclinical research.
Landis, Story C. 1; Amara, Susan G. 2; Asadullah, Khusru 3; Austin, Chris P. 4; Blumenstein, Robi 5; Bradley, Eileen W. 6; Crystal, Ronald G. 7; Darnell, Robert B. 8; Ferrante, Robert J. 9; Fillit, Howard 10; Finkelstein, Robert 1; Fisher, Marc 11; Gendelman, Howard E. 12; Golub, Robert M. 13; Goudreau, John L. 14; Gross, Robert A. 15; Gubitz, Amelie K. 1; Hesterlee, Sharon E. 16; Howells, David W. 17; Huguenard, John 18; Kelner, Katrina 19; Koroshetz, Walter 1; Krainc, Dimitri 20; Lazic, Stanley E. 21; Levine, Michael S. 22; Macleod, Malcolm R. 23; McCall, John M. 24; Moxley, Richard T. III 25; Narasimhan, Kalyani 26; Noble, Linda J. 27; Perrin, Steve 28; Porter, John D. 1; Steward, Oswald 29; Unger, Ellis 30; Utz, Ursula 1; Silberberg, Shai D. 1
[Miscellaneous Article]
Nature.
490(7419):187-191, October 11, 2012.
(Format: HTML, PDF)
: The US National Institute of Neurological Disorders and Stroke convened major stakeholders in June 2012 to discuss how to improve the methodological reporting of animal studies in grant applications and publications. The main workshop recommendation is that at a minimum studies should report on sample-size estimation, whether and how animals were randomized, whether investigators were blind to the treatment, and the handling of data. We recognize that achieving a meaningful improvement in the quality of reporting will require a concerted effort by investigators, reviewers, funding agencies and journal editors. Requiring better reporting of animal studies will raise awareness of the importance of rigorous study design to accelerate scientific progress.
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