Expression of a Delta homologue in prospective neurons in the chick.
Henrique, Domingos; Adam, Julie; Myat, Anna; Chitnis, Ajay; Lewis, Julian; Ish-Horowicz, David
[Letter]
Nature.
375(6534):787-790, June 29, 1995.
(Format: HTML)
The product of the Delta gene, acting as ligand, and that of the Notch gene, acting as receptor, are key components in a lateral-inhibition signalling pathway that regulates the detailed patterning of many different tissues in Drosophila [1-8]. During neurogenesis in particular, neural precursors, by expressing Delta, inhibit neighbouring Notch-expressing cells from becoming committed to a neural fate [5,9,10]. Vertebrates are known to have several Notch genes [11-14], but their functions are unclear and their ligands hitherto unidentified. Here we identify and describe a chick Delta homologue, C-Delta-1. We show that C-Delta-1 is expressed in prospective neurons during neurogenesis, as new cells are being born and their fates decided. Our data from the chick, combined with parallel evidence from Xenopus [15], suggest that both the Delta/Notch signalling mechanism and its role in neurogenesis have been conserved in vertebrates.
(C) 1995 Macmillan Magazines Ltd.