Information de reference pour ce titreAccession Number: | 00005597-200702000-00019.
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Author: | Gast, A 1; Bermejo, J L 1; Flohr, T 2; Stanulla, M 3; Burwinkel, B 1; Schrappe, M 4; Bartram, C R 2; Hemminki, K 1,5; Kumar, R 1,6
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Institution: | (1)Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany; (2)Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany; (3)Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany; (4)Department of Pediatrics, University of Kiel, Kiel, Germany; (5)Center for Family Medicine, Karolinska Institute, Huddinge, Sweden and (6)Department of Biosciences and Nutrition, Karolinska Institute, Huddinge, Sweden
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Title: | Folate metabolic gene polymorphisms and childhood acute lymphoblastic leukemia: a case-control study.[Article]
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Source: | Leukemia. 21(2):320-325, February 2007.
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Abstract: | We genotyped six folate metabolic pathway genes for 11 polymorphisms in 460 cases of childhood acute lymphoblastic leukemia (ALL) and 552 ethnically matched controls. None of the polymorphisms except the 66A > G (I22M) in the 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) gene showed any effect on disease risk. The carriers of the G-allele were associated with a marginal decreased risk of ALL (gender-adjusted global P = 0.03; multiple-testing corrected P = 0.25). Analysis of four polymorphisms in the MTRR gene showed statistically significant differences in haplotype distribution between cases and controls (global P < 0.0001). The haplotypes GCAC (odds ratio (OR) 0.5, 95% confidence interval (CI) 0.4-0.6) and ATAC (OR 0.5, 95% CI 0.3-0.6) were associated with a reduced risk and the haplotypes ACAC (OR 2.3, 95% CI 1.8-2.9) and GTAC (OR 1.8, 95% CI 1.4-2.3) with an increased risk. The genotype-combination analyses indicated that the best model stratifies cases and controls based on the 66A > G and the 524C > T polymorphisms in the MTRR gene (global P = 0.03). Our results suggest that, besides a weak association of childhood ALL with the 66A > G polymorphism, haplotypes within the MTRR gene may, in part, account for population-based differences in risk.
Copyright (C) 2007 Nature Publishing Group
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Author Keywords: | acute lymphoblastic leukemia; folate metabolic pathway; polymorphism; genotype.
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Language: | English.
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Document Type: | Original Article: Genomics.
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Journal Subset: | Clinical Medicine.
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ISSN: | 0887-6924
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NLM Journal Code: | leu, 8704895
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