Information de reference pour ce titreAccession Number: | 00005407-199508300-00038.
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Author: | Reid, M. Carrington; Lachs, Mark S.; Feinstein, Alvan R.
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Institution: | From the Robert Wood Johnson Clinical Scholars Program (Dr Reid) and Departments of Internal Medicine and Epidemiology (Dr Feinstein), Yale University School of Medicine, New Haven, Conn; and the Division of General Internal Medicine, The New York (NY) Hospital-Cornell University School of Medicine (Dr Lachs). Reprint requests to the Robert Wood Johnson Clinical Scholars Program, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520-8025 (Dr Feinstein).
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Title: | Use of Methodological Standards In Diagnostic Test Research: Getting Better But Still Not Good.[Review]
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Source: | JAMA. 274(8):645-651, Aug 23, 1995.
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Abstract: | Objective: To determine the frequency and temporal changes in application of seven accepted methodological standards for the evaluation of diagnostic tests.
Data Sources: A search of the MEDLINE database yielded 1302 articles about diagnostic test studies, during a 16-year secular interval, 1978 through 1993, in four prominent general medical journals.
Study Selection.In the 112 eligible studies, the test was intended for clinical use, indexes of accuracy (sensitivity and specificity or likelihood ratios) were provided, and more than 10 patients were enrolled.
Data Extraction: Although each study was critically reviewed by one primary observer, a subset was independently evaluated for interrater consistency.
Data Synthesis: The percentage of studies that fulfilled criteria for each of the seven methodological standards are as follows: (1) specify spectrum of evaluated patients, 27%; (2) report test indexes for clinical subgroups, 8%; (3) avoid workup bias, 46%; (4) avoid review bias, 38%; (5) provide numerical precision for test indexes, 11%; (6) report frequency and management of indeterminate results when calculating test indexes, 22%; and (7) specify test reproducibility, 23%. Secular increases were found for six of the seven standards in ranges of use from 14% to 31% during 1978-1981 to 1990-1993. Nevertheless, only one standard, avoidance of workup bias, was fulfilled by more than 50% of studies in the most recent secular interval.
Conclusions: These results indicate that most diagnostic tests are still inadequately appraised. The routine demand for methodological standards could raise the quality of diagnostic test information, and the careful predissemination evaluation of diagnostic tests could eliminate useless tests before they receive widespread application.(JAMA. 1995;274:645-651)
Copyright 1995 by the American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use. American Medical Association, 515 N. State St, Chicago, IL 60610.
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Language: | English.
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Document Type: | Review.
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Journal Subset: | Clinical Medicine.
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ISSN: | 0098-7484
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NLM Journal Code: | 7501160
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