Information de reference pour ce titreAccession Number: | 00003571-201107000-00008.
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Author: | Salpeter, Seth J.; Klochendler, Agnes; Weinberg-Corem, Noa; Porat, Shay; Granot, Zvi; Shapiro, A. M. James; Magnuson, Mark A.; Eden, Amir; Grimsby, Joseph; Glaser, Benjamin; Dor, Yuval
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Institution: | Department of Developmental Biology and Cancer Research (S.J.S., A.K., N.W.-C., S.P., Z.G., Y.D.), The Institute for Medical Research Israel-Canada, and Endocrinology and Metabolism Service (B.G.), Department of Internal Medicine, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel; Department of Cell and Developmental Biology (A.K., A.E.), Institute of Life Sciences, and Department of Obstetrics and Gynecology (S.P.), Division of Obstetrics, Hadassah Medical Center, Hebrew University, Jerusalem 91904, Israel; Department of Surgery and the Clinical Islet Transplant Program (A.M.J.S.), University of Alberta, Edmonton, Alberta, Canada AB T6G 2M7; Department of Cell and Developmental Biology (M.A.M.), Vanderbilt University School of Medicine, Nashville, Tennessee 37232; and Department of Metabolic Diseases (J.G.), Hoffmann-La Roche, Nutley, New Jersey 07110
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Source: | Endocrinology. 152(7):2589-2598, July 2011.
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Abstract: | Understanding the molecular triggers of pancreatic [beta]-cell proliferation may facilitate the development of regenerative therapies for diabetes. Genetic studies have demonstrated an important role for cyclin D2 in [beta]-cell proliferation and mass homeostasis, but its specific function in [beta]-cell division and mechanism of regulation remain unclear. Here, we report that cyclin D2 is present at high levels in the nucleus of quiescent [beta]-cells in vivo. The major regulator of cyclin D2 expression is glucose, acting via glycolysis and calcium channels in the [beta]-cell to control cyclin D2 mRNA levels. Furthermore, cyclin D2 mRNA is down-regulated during S-G2-M phases of each [beta]-cell division, via a mechanism that is also affected by glucose metabolism. Thus, glucose metabolism maintains high levels of nuclear cyclin D2 in quiescent [beta]-cells and modulates the down-regulation of cyclin D2 in replicating [beta]-cells. These data challenge the standard model for regulation of cyclin D2 during the cell division cycle and suggest cyclin D2 as a molecular link between glucose levels and [beta]-cell replication.
Copyright (C) Oxford University Press 2015
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References: | 1. Dor Y, Brown J, Martinez OI, Melton DA 2004 Adult pancreatic [beta]-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429:41-46
2. Nir T, Melton DA, Dor Y 2007 Recovery from diabetes in mice by [beta] cell regeneration. J Clin Invest 117:2553-2561
3. Teta M, Rankin MM, Long SY, Stein GM, Kushner JA 2007 Growth and regeneration of adult [beta] cells does not involve specialized progenitors. Dev Cell 12:817-826
4. Georgia S, Bhushan A 2004 [beta] Cell replication is the primary mechanism for maintaining postnatal [beta] cell mass. J Clin Invest 114:963-968
5. Cano DA, Rulifson IC, Heiser PW, Swigart LB, Pelengaris S, German M, Evan GI, Bluestone JA, Hebrok M 2008 Regulated [beta]-cell regeneration in the adult mouse pancreas. Diabetes 57:958-966
6. Salpeter SJ, Klein AM, Huangfu D, Grimsby J, Dor Y 2010 Glucose and aging control the quiescence period that follows pancreatic [beta] cell replication. Development 137:3205-3213
7. Meier JJ, Butler AE, Saisho Y, Monchamp T, Galasso R, Bhushan A, Rizza RA, Butler PC 2008 [beta]-Cell replication is the primary mechanism subserving the postnatal expansion of [beta]-cell mass in humans. Diabetes 57:1584-1594
8. Sherr CJ, Roberts JM 1999 CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13:1501-1512
9. Sherr CJ, Roberts JM 2004 Living with or without cyclins and cyclin-dependent kinases. Genes Dev 18:2699-2711
10. Matsushime H, Quelle DE, Shurtleff SA, Shibuya M, Sherr CJ, Kato JY 1994 D-type cyclin-dependent kinase activity in mammalian cells. Mol Cell Biol 14:2066-2076
11. Matsushime H, Roussel MF, Ashmun RA, Sherr CJ 1991 Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell 65:701-713
12. Sicinski P, Donaher JL, Geng Y, Parker SB, Gardner H, Park MY, Robker RL, Richards JS, McGinnis LK, Biggers JD, Eppig JJ, Bronson RT, Elledge SJ, Weinberg RA 1996 Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Nature 384:470-474
13. Weber JD, Raben DM, Phillips PJ, Baldassare JJ 1997 Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase. Biochem J 326(Pt 1):61-68
14. Guttridge DC, Albanese C, Reuther JY, Pestell RG, Baldwin AS Jr 1999 NF-[kappa]B controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol Cell Biol 19:5785-5799
15. Shtutman M, Zhurinsky J, Simcha I, Albanese C, D'Amico M, Pestell R, Ben-Ze'ev A 1999 The cyclin D1 gene is a target of the [beta]-catenin/LEF-1 pathway. Proc Natl Acad Sci USA 96:5522-5527
16. Watanabe G, Howe A, Lee RJ, Albanese C, Shu IW, Karnezis AN, Zon L, Kyriakis J, Rundell K, Pestell RG 1996 Induction of cyclin D1 by simian virus 40 small tumor antigen. Proc Natl Acad Sci USA 93:12861-12866
17. White PC, Shore AM, Clement M, McLaren J, Soeiro I, Lam EW, Brennan P 2006 Regulation of cyclin D2 and the cyclin D2 promoter by protein kinase A and CREB in lymphocytes. Oncogene 25:2170-2180
18. Martino A, Holmes JH 4th, Lord JD, Moon JJ, Nelson BH 2001 Stat5 and Sp1 regulate transcription of the cyclin D2 gene in response to IL-2. J Immunol 166:1723-1729
19. Kushner JA, Ciemerych MA, Sicinska E, Wartschow LM, Teta M, Long SY, Sicinski P, White MF 2005 Cyclins D2 and D1 are essential for postnatal pancreatic [beta]-cell growth. Mol Cell Biol 25:3752-3762
20. Kushner JA 2006 [beta]-Cell growth: an unusual paradigm of organogenesis that is cyclin D2/Cdk4 dependent. Cell Cycle 5:234-237
21. Georgia S, Hinault C, Kawamori D, Hu J, Meyer J, Kanji M, Bhushan A, Kulkarni RN 2010 Cyclin D2 is essential for the compensatory [beta]-cell hyperplastic response to insulin resistance in rodents. Diabetes 59:987-996
22. Rulifson IC, Karnik SK, Heiser PW, Ten Berge D, Chen H, Gu X, Taketo MM, Nusse R, Hebrok M, Kim SK 2007 Wnt signaling regulates pancreatic [beta] cell proliferation. Proc Natl Acad Sci USA 104:6247-6252
23. Fatrai S, Elghazi L, Balcazar N, Cras-Meneur C, Krits I, Kiyokawa H, Bernal-Mizrachi E 2006 Akt induces [beta]-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity. Diabetes 55:318-325
24. Heit JJ, Apelqvist AA, Gu X, Winslow MM, Neilson JR, Crabtree GR, Kim SK 2006 Calcineurin/NFAT signalling regulates pancreatic [beta]-cell growth and function. Nature 443:345-349
25. Alonso LC, Yokoe T, Zhang P, Scott DK, Kim SK, O'Donnell CP, Garcia-Ocana A 2007 Glucose infusion in mice: a new model to induce [beta]-cell replication. Diabetes 56:1792-1801
26. Friedrichsen BN, Richter HE, Hansen JA, Rhodes CJ, Nielsen JH, Billestrup N, Moldrup A 2003 Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic [beta]-cells. Mol Endocrinol 17:945-958
27. He LM, Sartori DJ, Teta M, Opare-Addo LM, Rankin MM, Long SY, Diehl JA, Kushner JA 2009 Cyclin D2 protein stability is regulated in pancreatic [beta]-cells. Mol Endocrinol 23:1865-1875
28. Weinberg N, Ouziel-Yahalom L, Knoller S, Efrat S, Dor Y 2007 Lineage tracing evidence for in vitro dedifferentiation but rare proliferation of mouse pancreatic [beta]-cells. Diabetes 56:1299-1304
29. Grimsby J, Sarabu R, Corbett WL, Haynes NE, Bizzarro FT, Coffey JW, Guertin KR, Hilliard DW, Kester RF, Mahaney PE, Marcus L, Qi L, Spence CL, Tengi J, Magnuson MA, Chu CA, Dvorozniak MT, Matschinsky FM, Grippo JF 2003 Allosteric activators of glucokinase: potential role in diabetes therapy. Science 301:370-373
30. Bolger GT, Weissman BA, Skolnick P 1985 The behavioral effects of the calcium agonist Bay K 8644 in the mouse: antagonism by the calcium antagonist nifedipine. Naunyn Schmiedebergs Arch Pharmacol 328:373-377
31. Ohsugi M, Cras-Meneur C, Zhou Y, Warren W, Bernal-Mizrachi E, Permutt MA 2004 Glucose and insulin treatment of insulinoma cells results in transcriptional regulation of a common set of genes. Diabetes 53:1496-1508
32. Gu G, Dubauskaite J, Melton DA 2002 Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129:2447-2457
33. Postic C, Shiota M, Niswender KD, Jetton TL, Chen Y, Moates JM, Shelton KD, Lindner J, Cherrington AD, Magnuson MA 1999 Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic [beta] cell-specific gene knock-outs using Cre recombinase. J Biol Chem 274:305-315
34. Porat S, Weinberg-Corem N, Tornovsky-Babaey S, Schyr-Ben-Haroush R, Hija A, Stolovich-Rain M, Dadon D, Granot Z, Ben-Hur V, White P, Girard CA, Karni R, Kaestner KH, Ashrcroft FM, Magnuson MA, Saada A, Grimsby J, Glaser B, Dor Y 2011 Control of pancreatic beta cell regeneration by glucose metabolism. Cell Metab 13:440-449
35. Wang W, Walker JR, Wang X, Tremblay MS, Lee JW, Wu X, Schultz PG 2009 Identification of small-molecule inducers of pancreatic [beta]-cell expansion. Proc Natl Acad Sci USA 106:1427-1432
36. Beith JL, Alejandro EU, Johnson JD 2008 Insulin stimulates primary [beta]-cell proliferation via Raf-1 kinase. Endocrinology 149:2251-2260
37. Baldin V, Lukas J, Marcote MJ, Pagano M, Draetta G 1993 Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev 7:812-821
38. Lukas J, Pagano M, Staskova Z, Draetta G, Bartek J 1994 Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines. Oncogene 9:707-718
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Language: | English.
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Document Type: | Diabetes-Insulin-Glucagon-Gastrointestinal.
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Journal Subset: | Clinical Medicine.
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ISSN: | 0013-7227
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NLM Journal Code: | egz, 0375040
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DOI Number: | https://dx.doi.org/10.1210/en.20...- ouverture dans une nouvelle fenêtre
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