Mcl-1 and Bcl-xL are co-regulated by IL-6 in human myeloma cells.
Puthier, Denis 1; Derenne, Sophie 1; Barille, Sophie 1; Moreau, Phillipe 2; Harousseau, Jean-Luc 2; Bataille, Regis 1; Amiot, Martine 1
[Report] British Journal of Haematology. 107(2):392-395, November 1999.

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Summary. Multiple myeloma (MM) is a slowly proliferative malignancy in which malignant plasma cells accumulate within the bone marrow. The expression of several anti-apoptotic proteins was evaluated by immunoblotting in human myeloma cell lines and in highly purified native myeloma cells. Expression of Bcl-xL, Mcl-1 and Bcl-2 was found in most of the samples; expression of Bcl-xL and Mcl-1 seemed to be related on myeloma cells. In a system of apoptosis by growth factor deprivation on myeloma cells, we showed that the effect of Bcl-2 seemed minimal whereas Mcl-1 and Bcl-xL were tightly regulated by interleukin (IL)-6. These findings underline the important role of Mcl-1 and Bcl-xL instead of Bcl-2 in IL-6-induced survival of myeloma cells.

(C) 1999 Blackwell Science Ltd.