Xenobiotic Metabolism Genes and the Risk of Recurrent Spontaneous Abortion.
Hirvonen, Ari 1,2; Taylor, Jack A. 3; Wilcox, Allen 3; Berkowitz, Gertrud 4; Schachter, Beth 4; Chaparro, Carlos 4; Bell, Douglas A. 1
[Report] Epidemiology. 7(2):206-208, March 1996.

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We examined the relation between spontaneous abortion and polymorphisms in two genes, glutathione S-transferase (GSTMI) and N-acetyltransferase (NAT2), which are involved in the metabolism of xenobiotics. In a case-control study of 29 women, we found that, among women with the GSTMI null genotype, the odds ratio (OR) was 3.1 [95% confidence interval (Cl) = 1.3-7.0]. There was less evidence of a relation with NAT2 [Mantel-Haenszel adjusted OR (ORMH) = 1.4; 95% CI = 0.45-4.3]. We sought to replicate the GSTMI finding in an independent case-control study from New York involving 89 cases. We found an inverse association (OR = 0.8; 95% CI = 0.4-2.4). Taken together, these data provide little evidence of an association between GSTMI or NAT2 genotype and risk of spontaneous abortion.

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