Vitamin, Mineral, and Multivitamin Supplements for the Primary Prevention of Cardiovascular Disease and Cancer: U.S. Preventive Services Task Force Recommendation Statement.
Moyer, Virginia A. MD, MPH; on behalf of the U.S. Preventive Services Task Force *
[Miscellaneous Article] Annals of Internal Medicine. 160(8):558-564, April 15, 2014.

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Description: Update of the 2003 U.S. Preventive Services Task Force (USPSTF) recommendation on vitamin supplementation to prevent cardiovascular disease and cancer.

Methods: The USPSTF reviewed the evidence on the efficacy of multivitamin or mineral supplements in the general adult population for the prevention of cardiovascular disease and cancer.

Population: This recommendation applies to healthy adults without special nutritional needs (typically aged 50 years or older). It does not apply to children, women who are pregnant or may become pregnant, or persons who are chronically ill or hospitalized or have a known nutritional deficiency.

Recommendation: The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of multivitamins for the prevention of cardiovascular disease or cancer. (I statement)

The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of single- or paired-nutrient supplements (except [beta]-carotene and vitamin E) for the prevention of cardiovascular disease or cancer. (I statement)

The USPSTF recommends against [beta]-carotene or vitamin E supplements for the prevention of cardiovascular disease or cancer. (D recommendation)

(C) 2014 American College of Physicians