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Description: Update of the 2004 U.S. Preventive Services Task Force statement about screening for syphilis in pregnancy.

Methods: The U.S. Preventive Services Task Force did a targeted literature search for evidence on the benefits of screening, the harms of screening, and the harms of treatment of syphilis with penicillin during pregnancy.

Recommendation: Screen all pregnant women for syphilis infection. (Grade A recommendation.)

(C) 2009 American College of Physicians