Is secondary lymphoid-organ chemokine (SLC/CCL21) much more than a constitutive chemokine?.
Serra, H. M. 1; Baena-Cagnani, C. E. 2; Eberhard, Y. 1
[Article] Allergy. 59(11):1219-1223, November 2004.

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Chemokines are a superfamily of small cytokines with activities ranging from leukocyte traffick to hematopoiesis, angiogenesis, and tissue organogenesis. Secondary lymphoid-organ chemokine (SLC/CCL21) was originally reported as a chemokine constitutively expressed by stromal cells and high endothelial venules in secondary lymphoid tissues and endothelium of afferent lymphatics, directing CCR7 cells. More recently, others and we have demonstrated that SLC/CCL21 is up-regulated in different skin inflammatory conditions. Thereafter, this molecule is much more than a constitutive chemokine, which could play a role in effector and regulatory immune functions.

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