Extended Virulence Genotypes and Phylogenetic Background of Escherichia coli Isolates from Patients with Cystitis, Pyelonephritis, or Prostatitis.
Johnson, James R. 1,3; Kuskowski, Michael A. 2,4; Gajewski, Abby 1,3,a; Soto, Sara 5; Horcajada, Juan Pablo 5; de Anta, Teresa M. Jimenez 5; Vila, Jordi 5
[Article] Journal of Infectious Diseases. 191(1):46-50, January 1, 2005.

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: Molecular analysis of 63 Escherichia coli urine isolates showed that pyelonephritis (n = 23) and prostatitis (n = 17) isolates exhibited more virulence factors (VFs) among the 35 sought than did cystitis isolates (n = 23). Several nontraditional VFs-including bmaE (M fimbriae), gafD (G fimbriae), fyuA (yersiniabactin receptor), ireA and iroN (novel siderophore receptors), cvaC (colicin [microcin] V), traT (serum-resistance associated), ibeA (invasion of brain endothelium), ompT (outer membrane protease T), and malX (pathogenicity island marker)-either differentiated significantly between syndromes (despite small numbers of isolates and possible multiple-comparison artifacts) or were broadly prevalent. Thus, interventions that target conserved uro-VFs may be possible, despite the likely existence of syndrome-specific pathogenetic mechanisms and/or host defense systems.

(C) Copyright Oxford University Press 2005.