Information de reference pour ce titreAccession Number: | 01445364-200805000-00008.
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Author: | Rostami, Nematollah 1; Keshtkar-Jahromi, Maryam 2; Rahnavardi, Mohammad 3*; Keshtkar-Jahromi, Marzieh 4; Esfahani, Fatemeh Soghra 5
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Institution: | (1)Hematology Department, Shaheed Modarres Medical Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran; (2)Infectious Diseases and Tropical Medicine Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran; (3)Didegan-Salamat Research Institute, Tehran, Iran; (4)Medical School, Azad University of Kazeroon, Kazeroon, Iran; (5)Hematology Department, Taleghani Medical Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
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Title: | |
Source: | American Journal Of Hematology. 83(5):376-381, May 2008.
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Abstract: | : Several recent studies have suggested that an association exists between Helicobacter pylori (HP) eradication and improvement in platelet count in a significant proportion of patients with idiopathic thrombocytopenic purpura (ITP). In this controlled study, we prospectively examined adult patients with chronic ITP for HP infection, and assessed the effect of HP eradication on platelet count. One hundred forty-two consecutive Iranian patients with chronic ITP were assessed. Those who met the criteria and had platelet counts >=30 x 109/L within the medication-free screening month were enrolled (n = 129; 66 females; mean age, 29.2 +/- 7.0 years). HP-positive patients received a 2-week course of triple HP eradication therapy (i.e., amoxicillin, clarithromycin, and omeprazole) and were followed for 48 weeks. An ITP response was defined as a platelet count of >100 x 109/L 24 weeks after treatment, together with an increase in the platelet count >30 x 109/L over the baseline value. HP infection was detected in 79 (61%) patients. HP-positive patients were significantly older than HP-negative subjects (P = 0.018). HP eradication was successful in 87% (62/71) of those who completed the eradication therapy. Whereas 48% (30/62) of HP-eradicated patients showed an ITP response, no HP-negative patient had an ITP response. The ITP response persisted for 48 weeks in 93% (28/30) of the responders. The ITP responders had a shorter disease duration than the nonresponders (P = 0.002). The management of mild-to-moderate chronic ITP in Iranian patients, especially those with a recent onset of disease, should include an investigation for and eradication of infection with HP.
Copyright (C) 2008 John Wiley & Sons, Inc.
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Language: | English.
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Document Type: | article.
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Journal Subset: | Clinical Medicine.
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ISSN: | 0361-8609
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DOI Number: | https://dx.doi.org/10.1002/ajh.2...- ouverture dans une nouvelle fenêtre
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