Identification of UDP-glucuronosyltransferases involved in the metabolism of silymarin flavonolignans.
Vrba, Jiri a, *; Papouskova, Barbora b; Lnenickova, Katerina a; Kosina, Pavel a; Kren, Vladimir c; Ulrichova, Jitka a
[Article] Journal of Pharmaceutical and Biomedical Analysis. 178:112972, January 30, 2020.

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* Glucuronidation of the flavonolignan constituents of silymarin was examined.

* Human hepatocytes, hepatic microsomes and recombinant UGT enzymes were used.

* The parent compounds and their metabolites were analyzed by a UHPLC-MS method.

* Each of the tested flavonolignans was metabolized in vitro by multiple UGTs.

* UGT1A1 and UGT1A9 primarily metabolized the flavonolignans in silymarin.

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