Simultaneous quantification of five biflavonoids in rat plasma by LC-ESI-MS/MS and its application to a comparatively pharmacokinetic study of Selaginella doederleinii Hieron extract in rats.
Chen, Bing a,1; Wang, Xuewen a,1; Zou, Yulian b; Chen, Weiying a; Wang, Gang a; Yao, Wensong a; Shi, Peiying c; Li, Shaoguang a; Lin, Shilan a; Lin, Xinhua a,*; Yao, Hong a,*
[Miscellaneous Article] Journal of Pharmaceutical and Biomedical Analysis. 149:80-88, February 2018.

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* In silico assessment of the main biflavones in SDEA extract was performed at first.

* A LC-MS/MS method was originally developed for analysis of 5 biflavones in rat plasma.

* PK profiles of the main biflavones were studied firstly in rats.

* Bioavailability of the main biflavones were disclosed for the first time.

(C) 2018Elsevier, Inc.