Polymorphisms of interleukin-10 and tumour necrosis factor-[alpha] genes are associated with newly diagnosed and recurrent pulmonary tuberculosis.
OH, JAE-HEE 1; YANG, CHUL-SU 1; NOH, YEON-KYEONG 1; KWEON, YU-MI 1; JUNG, SUNG-SOO 2; SON, JI WOONG 4; KONG, SUCK-JUN 5; YOON, JANG UK 5; LEE, JI-SOOK 1; KIM, HWA-JUNG 1,3; PARK, JEONG-KYU 1,3; JO, EUN-KYEONG 1,3; SONG, CHANG-HWA 1,3
[Miscellaneous]
Respirology.
12(4):594-598, July 2007.
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Background and objectives: The genetic determinants for developing TB or having recurrent TB are unknown. The present study investigated the relationship between susceptibility to tuberculosis and human tumour necrosis factor-[alpha] (TNF-[alpha]) and interleukin-10 genes (IL-10).
Methods: A case-control study was conducted using two groups of cases-newly diagnosed TB (N-TB) and recurrent TB (R-TB)-and a control group.
Results: One hundred and seventeen healthy controls, 80 newly diagnosed TB patients and 65 patients with recurrent TB were enrolled. There was no significant difference in the TNF-[alpha] -308 G/A genotype between the TB patient groups and the controls. The IL-10 -1082A alleles were markedly over-represented among the TB patient groups compared with the control subjects, however, there was no significant difference in the IL-10 genotype frequency between the N-TB and R-TB patient groups.
Conclusion: The -1082A allele of the IL-10 gene may be important in determining susceptibility to TB, however, the -308 allele of the TNF-[alpha] gene does not affect differential TB susceptibility.
Copyright (C) 2007 Blackwell Publishing Ltd.
