Cell Type-Specific Involvement of RIG-I in Antiviral Response.
Kato, Hiroki 1; Sato, Shintaro 2; Yoneyama, Mitsutoshi 3; Yamamoto, Masahiro 1; Uematsu, Satoshi 1; Matsui, Kosuke 1; Tsujimura, Tohru 4; Takeda, Kiyoshi 5; Fujita, Takashi 3; Takeuchi, Osamu 1,2; Akira, Shizuo 1,2,*
[Article]
Immunity.
23(1):19-28, July 2005.
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Summary: Toll-like receptors (TLRs) play an important role in antiviral response by recognizing viral components. Recently, a RNA helicase, RIG-I, was also suggested to recognize viral double-stranded RNA. However, how these molecules contribute to viral recognition in vivo is poorly understood. We show by gene targeting that RIG-I is essential for induction of type I interferons (IFNs) after infection with RNA viruses in fibroblasts and conventional dendritic cells (DCs). RIG-I induces type I IFNs by activating IRF3 via I[kappa]B kinase-related kinases. In contrast, plasmacytoid DCs, which produce large amounts of IFN-[alpha], use the TLR system rather than RIG-I for viral detection. Taken together, RIG-I and the TLR system exert antiviral responses in a cell type-specific manner.
(C) 2005Elsevier, Inc.