Reliability of efficacy in men with erectile dysfunction treated with tadalafil once daily after initial success.
Shabsigh, R 1; Donatucci, C 2; Costabile, R 3; Perelman, M A 4; Burns, P 5; Zeigler, H 5; Wong, D G 5
[Article] International Journal of Impotence Research. 22(1):1-8, January/February 2010.

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: The reliability of response to treatment is an important component of erectile dysfunction (ED) treatment. This study examined the reliability of tadalafil once daily (that is, successful attempts/total attempts) following initial successful intercourse. Data pooled from two randomized, double-blind, placebo-controlled trials of men with ED who received tadalafil 2.5mg (N=96), tadalafil 5mg (N=206) or placebo (N=148) once daily were analyzed to determine the first-attempt success rate and subsequent reliability of response. The first-attempt success rate (Sexual Encounter Profile question 3 (SEP3)) was significantly higher among men taking tadalafil 2.5mg (45.7%) and 5mg (55.2%) compared to placebo (28.5%; P<0.05 and P<0.001, respectively). Furthermore, following initial success, men taking tadalafil 5mg had a significantly greater proportion of successful intercourse (SEP3) on subsequent attempts (85.9%, P<0.001) compared to men taking placebo (70.2%). Overall, men with ED taking tadalafil once daily experienced a high rate of reliability of efficacy.

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